The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations.

ABSTRACT: Introduction: Investigating variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic (PGx) relationships. ADME gene variation is relatively well characterized in European and Asian populations, but data from African populations are under-studied-which has implications for drug safety and effective use in Africa. Results: We identified significant ADME gene variation in African populations using data from 458 high-coverage whole genome sequences, 412 of which are novel, and from previously available African sequences from the 1,000 Genomes Project. ADME variation was not uniform across African populations, particularly within high impact coding variation. Copy number variation was detected

SUBMITTER: da Rocha JEB 

PROVIDER: S-EPMC8549571 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature