The Invasin and Complement-Resistance Protein Rck of Salmonella is More Widely Distributed than Previously Expected.

ABSTRACT: The rck open reading frame (ORF) on the pefI-srgC operon encodes an outer membrane protein responsible for invasion of nonphagocytic cell lines and resistance to complement-mediated killing. Until now, the rck ORF was only detected on the virulence plasmids of three serovars of Salmonella subsp. enterica (i.e., Bovismorbificans, Enteritidis, and Typhimurium). The increasing number of Salmonella genome sequences allowed us to use a combination of reference sequences and whole-genome multilocus sequence typing (wgMLST) data analysis to probe the presence of the operon and of rck in a wide array of isolates belonging to all Salmonella species and subspecies. We established the presence of partial or complete operons in 61 subsp. enterica serovars as w

SUBMITTER: Koczerka M 

PROVIDER: S-EPMC8549739 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature