An Assessment of Serological Assays for SARS-CoV-2 as Surrogates for Authentic Virus Neutralization.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has since caused a global pandemic resulting in millions of cases and deaths. Diagnostic tools and serological assays are critical for controlling the outbreak, especially assays designed to quantitate neutralizing antibody levels, considered the best correlate of protection. As vaccines become increasingly available, it is important to identify reliable methods for measuring neutralizing antibody responses that correlate with authentic virus neutralization but can be performed outside biosafety level 3 (BSL3) laboratories. While many neutralizing assays using pseudotyped virus have been developed, there have been few studies comparing the different assays to each other as surrogates for authentic virus n

SUBMITTER: Wohlgemuth N 

PROVIDER: S-EPMC8549747 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature