Dataset Information

Multiple steady statehood: the roles of productive and extractive capacities.

ABSTRACT: This paper proposes a model of statehood, defined as elite extraction of resources from a subject population. Different from most of the existing literature, the size of the subject population evolves endogenously in a Malthusian fashion, and the elite take into account the effects on future population levels when taxing the current population. The elite can spend extracted resources by investing in productive and extractive capacities. Productive capacity increases the size of the pie, while extractive capacity makes it easier for the elite to tax it. Together-but not each on its own-these two types of investment can give rise to multiple steady-state equilibria, such that one steady state has both a higher rate of extraction, and higher population density and output, than the other steady state. The model can also account for a positive empirical relationship between land productivity and state antiquity among countries with relatively late state development.

Supplementary information

The online version contains supplementary material available at 10.1007/s10887-021-09188-9.

SUBMITTER: Lagerlof NP

PROVIDER: S-EPMC8550320 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Multiple steady statehood: the roles of productive and extractive capacities.

Lagerlöf Nils-Petter NP

Journal of economic growth (Boston, Mass.) 20210313 2

This paper proposes a model of statehood, defined as elite extraction of resources from a subject population. Different from most of the existing literature, the size of the subject population evolves endogenously in a Malthusian fashion, and the elite take into account the effects on future population levels when taxing the current population. The elite can spend extracted resources by investing in productive and extractive capacities. Productive capacity increases the size of the pie, while ex ...[more]

PMID: 34720668

Similar Datasets

Project description:Multiplication of the invertebrate DNA baculoviruses activates the host DNA damage response (DDR), which promotes virus DNA replication. DDR signaling is initiated by the host insect's phosphatidylinositol-3 kinase-related kinases (PIKKs), including ataxia telangiectasia-mutated kinase (ATM). Like other PIKKs, ATM phosphorylates an array of host DDR proteins at serine/threonine glutamine (S/TQ) motifs, the result of which leads to cell cycle arrest, DNA repair, or apoptosis. To define the role of host PIKKs in baculovirus replication, we compared replication levels of the baculovirus prototype species Autographa californica multiple nucleopolyhedrovirus in permissive Spodoptera frugiperda (SF21) cells with and without ATM function. Caffeine, which inhibits multiple DDR kinases, and the ATM-specific inhibitors KU-55933 and KU-60019 each prevented phosphorylation of Spodoptera histone H2AX (SfH2AX), a recognized indicator of ATM activity. However, only caffeine reduced autographa californica multiple nucleopolyhedrovirus (AcMNPV)-induced bulk phosphorylation of S/TQ protein motifs. Furthermore, only caffeine, not KU-55933 or KU-60019, reduced AcMNPV yields, suggesting a limited role for ATM. To investigate further, we identified and edited the Spodoptera ATM gene (sfatm). Consistent with ATM's known functions, CRISPR/Cas9-mediated knockout of sfatm eliminated DNA damage-induced phosphorylation of DDR marker SfH2AX in SF21 cells. However, loss of sfatm failed to affect the levels of AcMNPV multiplication. These findings suggested that in the absence of the kinase SfATM, another caffeine-sensitive host DDR kinase promotes S/TQ phosphorylation and baculovirus multiplication. Thus, baculoviruses activate and utilize the host insect DDR in an ATM-independent manner. IMPORTANCE The DDR, while necessary for the maintenance and fidelity of the host genome, represents an important cellular response to viral infection. The prolific DNA baculoviruses activate and manipulate the invertebrate DDR by using mechanisms that positively impact virus multiplication, including virus DNA replication. As the key DDR initiator kinase, ATM was suspected to play a critical role in this host response. However, we show here that baculovirus AcMNPV activates an ATM-independent DDR. By identifying the insect host ATM ortholog (Spodoptera frugiperda SfATM) and evaluating genetic knockouts, we show that SfATM is dispensable for AcMNPV activation of the DDR and for virus replication. Thus, another PIKK, possibly the closely related kinase ATR (ATM- and Rad3-related kinase), is responsible for efficient baculovirus multiplication. These findings better define the host pathways used by invertebrates to engage viral pathogens, including DNA viruses.

Dataset Information

Multiple steady statehood: the roles of productive and extractive capacities.

Supplementary information

Publications

Multiple steady statehood: the roles of productive and extractive capacities.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets