Investigating microcrystalline cellulose crystallinity using Raman spectroscopy.

ABSTRACT: Microcrystalline cellulose (MCC) is a semi-crystalline material with inherent variable crystallinity due to raw material source and variable manufacturing conditions. MCC crystallinity variability can result in downstream process variability. The aim of this study was to develop models to determine MCC crystallinity index (%CI) from Raman spectra of 30 commercial batches using Raman probes with spot sizes of 100 µm (MR probe) and 6 mm (PhAT probe). A principal component analysis model separated Raman spectra of the same samples captured using the different probes. The %CI was determined using a previously reported univariate model based on the ratio of the peaks at 380 and 1096 cm^-1. The univariate model was adjusted for each probe. The %CI was also predicted from spectral data

SUBMITTER: Queiroz ALP 

PROVIDER: S-EPMC8550365 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature