Zinc oxide-induced changes to sunscreen ingredient efficacy and toxicity under UV irradiation.

ABSTRACT: Sunscreen safety and efficacy is generally evaluated based upon the properties of the individual chemicals in a formulation. However, the photostability of sunscreens has been shown to be highly dependent on the mixture of chemicals present. To better understand how sunscreen formulation influences stability, and to establish a foundation for probing the influence of zinc oxide additives, we formulated five different small-molecule based ultraviolet-filter (UV-filter) mixtures with a Sun Protection Factor (SPF) of 15. These mixtures contained active ingredients approved in either the United States or European Union and were designed to represent formulations of actual products on the market. We evaluated the photostability and toxicity of these mixtures in the absence and presence of zinc

SUBMITTER: Ginzburg AL 

PROVIDER: S-EPMC8550398 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature