Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8⁺ T-Cell Infiltration After Heart Transplantation.

ABSTRACT:

Background

The role of checkpoint axes in transplantation has been partially addressed in animal models but not in humans. Occurrence of fulminant myocarditis with allorejection-like immunologic features in patients under anti-PD1 (programmed death cell protein 1) treatment suggests a key role of the PD1/PD-L1 (programmed death ligand 1) axis in cardiac immune homeostasis.

Methods

We cross-sectionally studied 23 heart transplant patients undergoing surveillance endomyocardial biopsy. Endomyocardial tissue and peripheral blood mononuclear cells were analyzed by flow cytometry. Multivariate logistic regression analyses including demographic, clinical, and hemodynamic parameters were performed. Murine models were used to evaluate the impact of PD-L1 endothelial graft expression

SUBMITTER: Bracamonte-Baran W 

PROVIDER: S-EPMC8550427 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature