Adipose micro-grafts enhance tendinopathy healing in ovine model: An in vivo experimental perspective study.

ABSTRACT: In Europe, approximatively 100 000 to 500 000 tendon repairs are performed every year. These procedures are associated with a considerable rate of postoperative complications (from 6% to 11%). Autologous micro-grafts (AAMG) and stromal vascular fraction (SVF) have been shown to improve tendon healing in 60% to 70% of treated rodents. The purpose of this study was to evaluate the effects of AAMG in a sheep model with tendinopathy. We used sheep models because, as a large animal, they are more comparable to humans. The hypothesis was that SVF injection would improve tendon healing compared with the control group, reducing inflammatory and matrix degrading, while increasing anti-inflammatory expression and collagen synthesis in the early stage of tendon injury. Sixteen Apennine sheep aged 2 t

SUBMITTER: Palumbo Piccionello A 

PROVIDER: S-EPMC8550708 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature