Longitudinal humoral antibody response to SARS-CoV-2 infection among healthcare workers in a New York City hospital.

ABSTRACT:

Objective

Dynamics of humoral immune responses to SARS-CoV-2 antigens following infection suggest an initial decay of antibody followed by subsequent stabilisation. We aim to understand the longitudinal humoral responses to SARS-CoV-2 nucleocapsid (N) protein and spike (S) protein and to evaluate their correlation to clinical symptoms among healthcare workers (HCWs).

Design

A prospective longitudinal study.

Setting

This study was conducted in a New York City public hospital in the South Bronx, New York.

Participants

HCWs participated in phase 1 (N=500) and were followed up 4 months later in phase 2 (N=178) of the study. They underwent SARS-CoV-2 PCR and serology testing for N and S protein antibodies, in addition to completion of an online survey in both phases

SUBMITTER: Menon V 

PROVIDER: S-EPMC8550870 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature