Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan.

ABSTRACT: The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an antigen-presenting cell (APC). Here, the induction of adequate T cell activation and lineage specification is critical to mount protective immunity; at the same time, inadequate activation, which could lead to autoimmunity, must be avoided. mTOR forms highly conserved protein complexes 1 and 2 that shape lineage specification by integrating signals originating from TCR engagement, co-stimulatory or co-inhibitory receptors and cytokines and availability of nutrients. If one considers autoimmunity as the result of aberrant lineage specification in re

SUBMITTER: Geier C 

PROVIDER: S-EPMC8550885 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature