Ontology highlight
ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC8551071 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Huang Suihong S Wu Tan T Lau Alexander Y AY Au Cheryl C Huang Hao H Wang Xin X Kim Jin Young JY
iScience 20211009 11
Low reproducibility in gene expression profiles has been observed in transcriptome studies, and this often limits applying findings to clinical practice. Here, we show time-of-day effects on gene expression and analytical schemes to increase the reproducibility in expression patterns. We recruited patients with relapsing-remitting multiple sclerosis (RRMS) and healthy subjects and collected blood from individuals twice a day, day (2 pm) and night (9 pm). RNA sequencing analyses found that gene e ...[more]