Systematic discovery of signaling pathways linking immune activation to schizophrenia.

ABSTRACT: Immune activation has been shown to play a critical role in the development of schizophrenia; however its underlying mechanism remains unknown. Our report demonstrates a high-quality protein interaction network for schizophrenia (SCZ Network), constructed using our "neighborhood walk" approach in combination with "random walk with restart". The spatiotemporal expression pattern of the genes in this disease network revealed two developmental stages sensitive to perturbation by immune activation: mid-to late gestation, and adolescence. Furthermore, we induced immune activation at these stages in mice, carried out transcriptome sequencing on the mouse brains, and illustrated clear potential molecular pathways and key regulators correlating maternal immune activation during gestation and an in

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8551081 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature