In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum.

ABSTRACT: The neurochemical transmitter dopamine (DA) is implicated in a number of diseases states, including Parkinson's disease, schizophrenia, and drug abuse. DA terminal fields in the dorsal striatum and core region of the nucleus accumbens in the rat brain are organized as heterogeneous domains exhibiting fast and slow kinetic of DA release. The rates of dopamine release are significantly and substantially faster in the fast domains relative to the slow domains. The striatum is composed of a mosaic of spatial compartments known as the striosomes (patches) and the matrix. Extensive literature exists on the spatial organization of the patch and matrix compartments and their functions. However, little is known about these compartments as they relate to fast and slow kinetic DA domains observed by

SUBMITTER: Jaquins-Gerstl A 

PROVIDER: S-EPMC8551084 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature