Investigation into the foundations of the track-event theory of cell survival and the radiation action model based on nanodosimetry.

ABSTRACT: This work aims at elaborating the basic assumptions behind the "track-event theory" (TET) and its derivate "radiation action model based on nanodosimetry" (RAMN) by clearly distinguishing between effects of tracks at the cellular level and the induction of lesions in subcellular targets. It is demonstrated that the model assumptions of Poisson distribution and statistical independence of the frequency of single and clustered DNA lesions are dispensable for multi-event distributions because they follow from the Poisson distribution of the number of tracks affecting the considered target volume. It is also shown that making these assumptions for the single-event distributions of the number of lethal and sublethal lesions within a cell would lead to an essentially exponential dose dependence

SUBMITTER: Ngcezu SA 

PROVIDER: S-EPMC8551112 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature