Oral Microbial Species and Virulence Factors Associated with Oral Squamous Cell Carcinoma.

ABSTRACT: The human microbiome has been the focus of numerous research efforts to elucidate the pathogenesis of human diseases including cancer. Oral cancer mortality is high when compared with other cancers, as diagnosis often occurs during late stages. Its prevalence has increased in the USA over the past decade and accounts for over 40,000 new cancer patients each year. Additionally, oral cancer pathogenesis is not fully understood and is likely multifactorial. To unravel the relationships that are associated with the oral microbiome and their virulence factors, we used 16S rDNA and metagenomic sequencing to characterize the microbial composition and functional content in oral squamous cell carcinoma (OSCC) tumor tissue, non-tumor tissue, and saliva from 18 OSCC patients. Results indicate a highe

SUBMITTER: Torralba MG 

PROVIDER: S-EPMC8551143 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature