Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders.

ABSTRACT:

Background

Manifold cognitive deficits have been reported in schizophrenia spectrum disorders, including disturbances in flexible updating to altered circumstances as well as stabilization deficits in the face of distractors. In this functional magnetic resonance imaging study, we examined the neural correlates of these deficits as two complementary components of predictive processing.

Methods

In 22 patients with schizophrenia spectrum disorders and 22 healthy matched control participants, we applied a serial predictive switch-drift task to assess flexibility as successful detection of prediction-rule switches, and stability as successfully ignoring distractors ("drifts").

Results

Patients compared with controls less reliably detected rule switches and also less effic

SUBMITTER: Standke I 

PROVIDER: S-EPMC8551223 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature