Biochemical mechanisms of period control within the mammalian circadian clock.

ABSTRACT: Genetically encoded biological clocks are found broadly throughout life on Earth, where they generate circadian (about a day) rhythms that synchronize physiology and behavior with the daily light/dark cycle. Although the genetic networks that give rise to circadian timing are now fairly well established, our understanding of how the proteins that constitute the molecular 'cogs' of this biological clock regulate the intrinsic timing, or period, of circadian rhythms has lagged behind. New studies probing the biochemical and structural basis of clock protein function are beginning to reveal how assemblies of dedicated clock proteins form and evolve through post-translational regulation to generate circadian rhythms. This review will highlight some recent advances providing important insight i

SUBMITTER: Philpott JM 

PROVIDER: S-EPMC8551309 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature