Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.

ABSTRACT: BH3 mimetics are increasingly used as anti-cancer therapeutics either alone or in conjunction with other chemotherapies. However, mounting evidence has also demonstrated that BH3 mimetics modulate varied amounts of apoptotic signaling in healthy immune populations. In order to maximize their clinical potential, it will be essential to understand how BH3 mimetics affect discrete immune populations and to determine how BH3 mimetic pressure causes immune system adaptation. Here we focus on the BCL-2 specific inhibitor venetoclax (ABT-199) and its effects following short-term and long-term BCL-2 blockade on T cell subsets. Seven day "short-term" ex vivo and in vivo BCL-2 inhibition led to divergent cell death sensitivity patterns in CD8⁺ T cells, CD4⁺ T cells, and Tregs r

SUBMITTER: Ludwig LM 

PROVIDER: S-EPMC8551340 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature