Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.

ABSTRACT: Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis. The mechanistic processes underlying the changes of brain tissue and networks toward increased seizure susceptibility are not fully understood. In rodents, injection of kainic acid (KA) ultimately leads to the development of spontaneous epileptic seizures, reflecting similar neuropathological characteristics as seen in patients with temporal lobe epilepsy (TLE). Although this model has significantly contributed to increased knowledge of epileptogenesis, it is technically demanding, costly to operate and hence not suitable for high-throughput screening of anti-epileptic drugs (AEDs). Zebrafish, a vertebrate with complementary advantages

SUBMITTER: Heylen L 

PROVIDER: S-EPMC8551382 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature