Spatially Covarying Patterns of Gray Matter Volume and Concentration Highlight Distinct Regions in Schizophrenia.

ABSTRACT: Introduction: Individuals with schizophrenia have consistent gray matter reduction throughout the cortex when compared to healthy individuals. However, the reduction patterns vary based on the quantity (concentration or volume) utilized by study. The objective of this study was to identify commonalities between gray matter concentration and gray matter volume effects in schizophrenia. Methods: We performed both univariate and multivariate analyses of case/control effects on 145 gray matter images from 66 participants with schizophrenia and 79 healthy controls, and processed to compare the concentration and volume estimates. Results: Diagnosis effects in the univariate analysis showed similar areas of volume and concentration reductions in the insula, occipitotemporal g

SUBMITTER: Rootes-Murdy K 

PROVIDER: S-EPMC8551386 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature