CircFAM114A2 Promotes Cisplatin Sensitivity via miR-222-3p/P27 and miR-146a-5p/P21 Cascades in Urothelial Carcinoma.

ABSTRACT:

Introduction

Circular RNAs (circRNAs) are non-coding RNAs that have the structure of a covalently closed loop. Increasing data have proven that circRNAs can influence the progression and chemotherapy sensitivity of tumors. Therefore, the underlying function and mechanisms of more circRNAs in progression and chemotherapy resistance are important.

Methods

We conducted RNA sequencing on five pairs of urothelial carcinoma samples and screened for circRNAs. CircFAM114A2 was found to be low expressed in urothelial carcinoma. The functions of circFAM114A2 in urothelial carcinoma were explored by cell cycle assay, IC₅₀ determination assay, cell proliferation assay, apoptosis assay, and tumorigenesis assay.

Results

We discovered that the levels of circFAM114A2 were

SUBMITTER: Lv J 

PROVIDER: S-EPMC8551855 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature