Efficacy and Safety of Dupilumab in Moderate-to-Severe Bullous Pemphigoid.

ABSTRACT:

Background

Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. As the main treatment for BP, systemic corticosteroids are often limited by their side effects. Safer treatment modalities are therefore needed. Dupilumab is a biologic agent used to treat BP in recent years.

Methods

Medical records of patients with moderate-to-severe BP were retrospectively reviewed. Twenty-four patients were included (follow-up period: 32 weeks), eight of whom received dupilumab in combination with methylprednisolone and azathioprine (dupilumab group) while the other 16 patients received methylprednisolone and azathioprine (conventional group). Response to dupilumab was evaluated by comparison of several parameters (time to stop new blister forma

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8552038 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature