Age-Related Variation in Sympathetic Nerve Distribution in the Human Spleen.

ABSTRACT: Introduction: The cholinergic anti-inflammatory pathway (CAIP) has been proposed as an efferent neural pathway dampening the systemic inflammatory response via the spleen. The CAIP activates the splenic neural plexus and a subsequent series of intrasplenic events, which at least require a close association between sympathetic nerves and T cells. Knowledge on this pathway has mostly been derived from rodent studies and only scarce information is available on the innervation of the human spleen. This study aimed to investigate the sympathetic innervation of different structures of the human spleen, the topographical association of nerves with T cells and age-related variations in nerve distribution. Materials and Methods: Spleen samples were retrieved from a diagnostic archive

SUBMITTER: Cleypool CGJ 

PROVIDER: S-EPMC8552063 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature