Common Factors Underlying Diverse Responses in Alcohol Use Disorder.

ABSTRACT:

Objective

Interindividual variation in responses to alcohol is substantial, posing challenges for medical management and for understanding the biological underpinnings of alcohol use disorders (AUD). It is important to understand whether diverse alcohol responses such as sedation, which is predictive of risk and partly heritable, occur concurrently or independently from responses such as blackouts and withdrawal. We hypothesized that latent factors accounting for sources of variance in diverse alcohol response phenotypes could be identified in a large, deeply phenotyped sample of patients with AUD.

Methods

We factor analyzed 17 alcohol response related items from the Alcohol Dependence Scale (ADS) in 938 individuals diagnosed with AUD via structured clinical interviews. Demo

SUBMITTER: Chebolu E 

PROVIDER: S-EPMC8552111 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature