Response to cardiac resynchronisation therapy in men and women: a secondary analysis of the SMART-AV randomised controlled trial.

ABSTRACT:

Objectives

There is a controversy about whether both sexes' response to cardiac resynchronisation therapy (CRT) is similar. We aimed to assess a causal effect of sex on CRT response.

Design

Secondary analysis of a randomised controlled trial (RCT) data. Doubly robust augmented-inverse-probability-weighted (AIPW) estimation of sex effect on CRT response.

Setting

The SmartDelay Determined Atrioventricular (AV) Optimisation (SMART-AV) RCT.

Participants

The SMART-AV RCT enrolled New York Heart Association class III-IV patients with heart failure (HF) with left ventricular ejection fraction (LVEF) ≤35% despite optimal medical therapy and QRS duration ≥120 ms, in sinus rhythm. After exclusion of those with missing outcome or covariates, 741 participants (age 66±11 ye

SUBMITTER: Howell S 

PROVIDER: S-EPMC8552143 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature