Elevated sCD40L in Secondary Progressive Multiple Sclerosis in Comparison to Non-progressive Benign and Relapsing Remitting Multiple Sclerosis.

ABSTRACT:

Background

The long-term prognosis of relapsing-remitting multiple sclerosis (RRMS) is usually unfavorable as most patients transition to secondary progressive multiple sclerosis (SPMS) with accumulative disability. A rare form of non-progressive multiple sclerosis (MS) also exists, known as benign MS (BMS or NPMS), which lacks disease progression defined as Expanded Disability Status Scale (EDSS) ≤3 after 15 years of disease onset without treatment.

Purpose

Our study aims to identify soluble plasma factors predicting disease progression in multiple sclerosis (MS).

Research design and study sample

We utilized Luminex multiplex to analyze plasma levels of 33 soluble factors, comparing 32 SPMS patients to age-, sex-, and disease duration-matched non-progressive BMS pati

SUBMITTER: Wu Q 

PROVIDER: S-EPMC8552403 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature