Conventional and Microwave-Assisted Synthesis, Antitubercular Activity, and Molecular Docking Studies of Pyrazole and Oxadiazole Hybrids.

ABSTRACT: Microwave-assisted organic reaction enhancement (MORE) has become more important in synthetic organic chemistry for efficient resource utilization. In this study, we synthesized bioactive compounds using both traditional and microwave methods. Microwave-assisted synthesis takes less time and produces higher yields and quality than conventional approaches. We reported the synthesis of N'-(1-(2-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazol-3(2H)-yl)ethylidene) substituted hydrazides (4a-t). We also tested them against two strains: M. tuberculosis H₃₇Ra and M. bovis BCG. Against M. tuberculosis H₃₇Ra, the compounds 4e, 4h, 4k, 4p, and 4s were the most effec

SUBMITTER: Desai NC 

PROVIDER: S-EPMC8552481 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature