M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury.

ABSTRACT: After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. Meanwhile, microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. However, the effect of microglia polarization on astrocytes is unclear. Here, we found that both microglia (CX3CR1⁺) and astrocytes (GFAP⁺) gathered at the lesion border at 14 days post-injury (dpi). The microglia accumulated along the inner border of and in direct contact with the astrocytes. M1-type microglia (iNOS⁺CX3

SUBMITTER: Yu SS 

PROVIDER: S-EPMC8552861 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature