Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in K_v channels.

ABSTRACT: Impaired coronary microvascular function (e.g., reduced dilation and coronary flow reserve) predicts cardiac mortality in obesity, yet underlying mechanisms and potential therapeutic strategies remain poorly understood. Mineralocorticoid receptor (MR) antagonism improves coronary microvascular function in obese humans and animals. Whether MR blockade improves in vivo regulation of coronary flow, a process involving voltage-dependent K⁺ (K_v) channel activation, or reduces coronary structural remodeling in obesity is unclear. Thus, the goals of this investigation were to determine the effects of obesity on coronary responsiveness to reductions in arterial PO₂ and potential involvement of K_v channels and whether the benefit of MR blockade involves i

SUBMITTER: Goodwill AG 

PROVIDER: S-EPMC8552965 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature