Coronary flow quantification estimated by dynamic 320-detector CT angiography: validation by ¹³N ammonia PET myocardial flow reserve.

ABSTRACT:

Objectives

Resting coronary flow index (rCFI) estimated by 320-detector low-dose dynamic coronary CT angiography (CCTA) is a direct flow quantification using intracoronary attenuation. We propose modified-rCFI from new protocol combining dynamic scan and standard CCTA using dose-modulation, and validate its consistency with quantitative values and ischemia depicted by ¹³N-ammonia PET (NH₃-PET).

Methods

46 patients who underwent dynamic CCTA and NH₃-PET for coronary artery disease were evaluated using original rCFI in 21 patients and modified-rCFI in 25 patients. Two types of rCFI were calculated for three major coronary arteries. Myocardial blood flow (MBF) at rest and stress, myocardial flow reserve (MFR), and the presence or absence of isch

SUBMITTER: Matsuo Y 

PROVIDER: S-EPMC8553190 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature