Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats.

ABSTRACT:

Background

Sleep disorders are highly prevalent among stroke survivors and impede stroke recovery. It is well established that melatonin has neuroprotective effects in animal models of ischemic stroke. However, as a modulator of endogenous physiological circadian rhythms, the effects of melatonin on poststroke sleep disorders remain unclear. In the present study, we investigated how melatonin delivered intraperitoneally once daily in the subacute phase after stroke onset, influencing neuronal survival, motor recovery, and sleep-wake profiles in rats.

Methods

Transient ischemic stroke in male Sprague-Dawley rats was induced with 30 min occlusion of the middle cerebral artery. Melatonin or vehicle was delivered intraperitoneally once daily in the subacute phase, from 2 to 7 da

SUBMITTER: Hao SM 

PROVIDER: S-EPMC8553311 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature