Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia.

ABSTRACT:

Background

Decidualization of the uterine mucosa drives the maternal adaptation to invasion by the placenta. Appropriate depth of placental invasion is needed to support a healthy pregnancy; shallow invasion is associated with the development of severe preeclampsia (sPE). Maternal contribution to sPE through failed decidualization is an important determinant of placental phenotype. However, the molecular mechanism underlying the in vivo defect linking decidualization to sPE is unknown.

Methods

Global RNA sequencing was applied to obtain the transcriptomic profile of endometrial biopsies collected from nonpregnant women who suffer sPE in a previous pregnancy and women who did not develop this condition. Samples were randomized in two cohorts, the training and the test set, to

SUBMITTER: Garrido-Gomez T 

PROVIDER: S-EPMC8553341 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature