Association of HER1 and HER2 Gene Variants in the Predisposition of Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a major health concern worldwide. A series of sequential accumulation of genetic and epigenetic changes are responsible for the initiation and progression of diseases via the normal > adenoma > carcinoma sequence. Genetic variants in crucial cancer-causing genes are known to mediate the risk of cancer.

Objective

In this case-control study, we examined single nucleotide polymorphism (SNP) in HER1 (rs763317 and rs3752651) and HER2 (rs1136201 and rs1058808) genes to assess their role in the susceptibility of CRC in a Saudi population.

Methods

TaqMan allelic discrimination assay was utilized to identify the genotypes in 163 normal and 143 CRC patients.

Results

In the overall analysis, the rs3752651 and rs1136201 were significan

SUBMITTER: Alanazi IO 

PROVIDER: S-EPMC8553481 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature