Dichotomous metabolic networks govern human ILC2 proliferation and function.

ABSTRACT: Group 2 innate lymphoid cells (ILC2s) represent innate homologs of type 2 helper T cells (T_H2) that participate in immune defense and tissue homeostasis through production of type 2 cytokines. While T lymphocytes metabolically adapt to microenvironmental changes, knowledge of human ILC2 metabolism is limited, and its key regulators are unknown. Here, we show that circulating 'naive' ILC2s have an unexpected metabolic profile with a higher level of oxidative phosphorylation (OXPHOS) than natural killer (NK) cells. Accordingly, ILC2s are severely reduced in individuals with mitochondrial disease (MD) and impaired OXPHOS. Metabolomic and nutrient receptor analysis revealed ILC2 uptake of amino acids to sustain OXPHOS at steady state. Following activation with interleukin-33 (IL-33)

SUBMITTER: Surace L 

PROVIDER: S-EPMC8553616 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature