Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment.

ABSTRACT:

Purpose

Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery followed by chemoradiation, outcomes remain poor, with median survival of only 15 months and a 5-year survival rate of 6.8%. A challenge in treating GBM is the heterogeneous integrity of the blood-brain barrier (BBB), which limits the bioavailability of systemic therapies to the brain. There is a growing interest in enhancing drug delivery by opening the BBB with the use of focused ultrasound (FUS). We hypothesize that an FUS-mediated BBB opening can enhance the delivery of etoposide for a therapeutic benefit in GBM.

Methods and materials

A murine glioma cell line (Pdgf⁺, Pten^-/-, P53^-/-) was orthotopically injected into B6(Cg)-Tyrc-2J/J mice to establi

SUBMITTER: Wei HJ 

PROVIDER: S-EPMC8553628 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature