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COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report.

ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

SUBMITTER: Leung WF 

PROVIDER: S-EPMC8553657 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report.

Leung Wayne F WF   Chorlton Samuel S   Tyson John J   Al-Rawahi Ghada N GN   Jassem Agatha N AN   Prystajecky Natalie N   Masud Shazia S   Deans Gregory D GD   Chapman Michael G MG   Mirzanejad Yazdan Y   Murray Melanie C M MCM   Wong Patrick H P PHP  

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20211029

This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations. ...[more]

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