The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles.

ABSTRACT: Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the cardiac intercalated disc. Two signaling hubs that play important biomechanical roles for cardiac and/or skeletal muscle physiology are the N2B and N2A regions in the giant protein titin. Prominent proteins associated with these regions in titin are chaperones Hsp90 and αB-crystallin, members of the four-and-a-half LIM (FHL) and muscle ankyrin repeat protein (Ankrd) families, as well as thin filament-associated proteins, such as myopalladin. This review highlights biological roles and properties of the titin N2B and N2A regions in health and disease. Special emphasis is placed on functions of Ankrd and FHL proteins as mechanosensors t

SUBMITTER: van der Pijl RJ 

PROVIDER: S-EPMC8553726 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature