Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory.

ABSTRACT: Changes in gene expression are a hallmark of learning and memory consolidation. Little is known about how alternative mRNA processing, particularly abundant in neuron-specific genes, contributes to these processes. Prototype RNA binding proteins of the neuronally expressed ELAV/Hu family are candidates for roles in learning and memory, but their capacity to cross-regulate and take over each other's functions complicate substantiation of such links. Honey bees Apis mellifera have only one elav/Hu family gene elavl2, that has functionally diversified by increasing alternative splicing including an evolutionary conserved microexon. RNAi knockdown demonstrates that ELAVL2 is required for learning and memory in bees. ELAVL2 is dynamically expressed with altered alternative splicing and subcellu

SUBMITTER: Ustaoglu P 

PROVIDER: S-EPMC8553928 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature