TKGWV2: an ancient DNA relatedness pipeline for ultra-low coverage whole genome shotgun data.

ABSTRACT: Estimation of genetically related individuals is playing an increasingly important role in the ancient DNA field. In recent years, the numbers of sequenced individuals from single sites have been increasing, reflecting a growing interest in understanding the familial and social organisation of ancient populations. Although a few different methods have been specifically developed for ancient DNA, namely to tackle issues such as low-coverage homozygous data, they require a 0.1-1× minimum average genomic coverage per analysed pair of individuals. Here we present an updated version of a method that enables estimates of 1st and 2nd-degrees of relatedness with as little as 0.026× average coverage, or around 18,000 SNPs from 1.3 million aligned reads per sample with average length of 62 bp-four t

SUBMITTER: Fernandes DM 

PROVIDER: S-EPMC8553948 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature