An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy.

ABSTRACT: Chemodynamic therapy as an emerging therapeutic strategy has been implemented for oncotherapy. However, the reactive oxygen species can be counteracted by the exorbitant glutathione (GSH) produced by the tumor cells before exerting the antitumor effect. Herein, borneol (NB) serving as a monoterpenoid sensitizer, and copper sulfide (CuS NPs) as an NIR-II photothermal agent were loaded in a thermo-responsive vehicle (NB/CuS@PCM NPs). Under 1,060-nm laser irradiation, the hyperthermia produced by CuS NPs can be used for photothermal therapy and melt the phase change material for drug delivery. In the acidity microenvironment, the CuS NPs released from NB/CuS@PCM NPs could degrade to Cu²⁺, then Cu²⁺ was reduced to Cu⁺ during the depletion of GSH. As Fenton-like

SUBMITTER: Huang B 

PROVIDER: S-EPMC8553991 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature