The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition.

ABSTRACT: The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on infected cells on the other. There are eight ligands for the activating receptor NKG2D in humans - MICA, MICB, ULBP1-6. Several of them are induced and surface-expressed on herpesvirus-infected cells to serve as danger signals to activate the immune system. Therefore, these ligands are frequently targeted for suppression by viral immune evasion mechanisms. Mechanisms to downregulate NKG2D ligands and thereby escape immune recognition have been identified in all other human herpesviruses (HHV), except for HHV-6A. In this study, we identify t

SUBMITTER: Chaouat AE 

PROVIDER: S-EPMC8554080 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature