P300 amplitude during a monetary incentive delay task predicts future therapy completion in individuals with major depressive disorder.

ABSTRACT:

Introduction

Treatment effectiveness for major depressive disorder (MDD) is often affected by client non-adherence, dropout, and non-response. Identification of client characteristics predicting successful treatment completion and/or response (i.e., symptom reduction) may be an important tool to increase intervention effectiveness. It is unclear whether neural attenuations in reward processing associated with MDD predict behavioral treatment outcome.

Methods

This study aimed to determine whether blunted neural responses to reward at baseline differentiate MDD (n = 60; 41 with comorbid anxiety) and healthy control (HC; n = 40) groups; and predict MDD completion of and response to 7-10 sessions of behavior therapy. Participants completed a monetary incentive delay (MID) task.

SUBMITTER: White EJ 

PROVIDER: S-EPMC8554135 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature