Beta-Adrenergic Blockade in Critical Illness.
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ABSTRACT:
SUBMITTER: Bruning R
PROVIDER: S-EPMC8554196 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Beta-Adrenergic Blockade in Critical Illness.
Bruning Rebecca R Dykes Hannah H Jones Timothy W TW Wayne Nathaniel B NB Sikora Newsome Andrea A
Frontiers in pharmacology 20211015
Catecholamine upregulation is a core pathophysiological feature in critical illness. Sustained catecholamine β-adrenergic induction produces adverse effects relevant to critical illness management. β-blockers (βB) have proposed roles in various critically ill disease states, including sepsis, trauma, burns, and cardiac arrest. Mounting evidence suggests βB improve hemodynamic and metabolic parameters culminating in decreased burn healing time, reduced mortality in traumatic brain injury, and imp ...[more]
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