Dexamethasone-Induced FKBP51 Expression in CD4⁺ T-Lymphocytes Is Uniquely Associated With Worse Asthma Control in Obese Children With Asthma.

ABSTRACT:

Introduction

There is evidence that obesity, a risk factor for asthma severity and morbidity, has a unique asthma phenotype which is less atopic and less responsive to inhaled corticosteroids (ICS). Peripheral blood mononuclear cells (PBMC) are important to the immunologic pathways of obese asthma and steroid resistance. However, the cellular source associated with steroid resistance has remained elusive. We compared the lymphocyte landscape among obese children with asthma to matched normal weight children with asthma and assessed relationship to asthma control.

Methods

High-dimensional flow cytometry of PBMC at baseline and after dexamethasone stimulation was performed to characterize lymphocyte subpopulations, T-lymphocyte polarization, proliferation (Ki-67+), and express

SUBMITTER: Tejwani V 

PROVIDER: S-EPMC8554235 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature