Small conductance calcium activated K⁺ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation.

ABSTRACT:

Background

Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion channels (SACs) and calcium channels play a role in this. The expression profile and calcium dependent activation makes the small conductance calcium activated K⁺ channel (K_Ca2.x) a candidate for coupling stretch induced increases in intracellular calcium through K⁺-efflux and thereby shortening of atrial refractoriness.

Objectives

We hypothesized that K_Ca2.x channel inhibitors can prevent the stretch induced shortening of AERP and protect the heart from AF.

Methods

The effect of K

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8554272 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature