Identification and Mapping of HBsAg Loss-Related B-Cell Linear Epitopes in Chronic HBV Patients by Peptide Array.

ABSTRACT: Identification of immunogenic targets against hepatitis B virus (HBV)-encoded proteins will provide crucial advances in developing potential antibody therapies. In this study, 63 treatment-naïve patients with chronic HBV infection and 46 patients who achieved hepatitis B surface antigen loss (sAg loss) following antiviral treatment were recruited. Moreover, six patients who transitioned from the hepatitis B e antigen-positive chronic infection phase (eAg⁺CInf) to the hepatitis phase (eAg⁺CHep) were enrolled from real-life clinical practice. Additionally, telbivudine-treated eAg⁺CHep patients and relapsers or responders from an off-treatment cohort were longitudinally studied. The frequencies and function of B cells were assessed by flow cytometry. We devise

SUBMITTER: Gu S 

PROVIDER: S-EPMC8554339 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature