Tale of two kinases: Protein kinase A and Ca²⁺/calmodulin-dependent protein kinase II in pre-diabetic cardiomyopathy.

ABSTRACT: Metabolic syndrome is a pre-diabetic state characterized by several biochemical and physiological alterations, including insulin resistance, visceral fat accumulation, and dyslipidemias, which increase the risk for developing cardiovascular disease. Metabolic syndrome is associated with augmented sympathetic tone, which could account for the etiology of pre-diabetic cardiomyopathy. This review summarizes the current knowledge of the pathophysiological consequences of enhanced and sustained β-adrenergic response in pre-diabetes, focusing on cardiac dysfunction reported in diet-induced experimental models of pre-diabetic cardiomyopathy. The research reviewed indicates that both protein kinase A and Ca²⁺/calmodulin-dependent protein kinase II play important roles in functional resp

SUBMITTER: Gaitan-Gonzalez P 

PROVIDER: S-EPMC8554373 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature