Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial.

ABSTRACT:

Background

Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with acute ischemic stroke. The aim of the Tenecteplase in Wake-up Ischemic Stroke Trial (TWIST) is to compare the effect of thrombolytic treatment with tenecteplase and standard care versus standard care alone in patients with wake-up ischemic stroke selected by non-contrast CT.

Methods/design

TWIST is an international, investigator-initiated, multi-centre, prospective, randomized-controlle

SUBMITTER: Roaldsen MB 

PROVIDER: S-EPMC8554491 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature