Renal subcapsular delivery of PGE₂ promotes kidney repair by activating endogenous Sox9⁺ stem cells.

ABSTRACT: Prostaglandin E₂ (PGE₂) has recently been recognized to play a role in immune regulation and tissue regeneration. However, the short half-life of PGE₂ limits its clinical application. Improving the delivery of PGE₂ specifically to the target organ with a prolonged release method is highly desirable. Taking advantage of the adequate space and proximity of the renal parenchyma, renal subcapsular delivery allows minimally invasive and effective delivery to the entire kidney. Here, we report that by covalently cross-linking it to a collagen matrix, PGE₂ exhibits an adequate long-term presence in the kidney with extensive intraparenchymal penetration through renal subcapsular delivery and significantly improves kidney function. Sox9 cell li

SUBMITTER: Chen S 

PROVIDER: S-EPMC8554536 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature