Striatal low-threshold spiking interneurons locally gate dopamine.

ABSTRACT: The dorsomedial striatum (DMS) is a central hub supporting goal-directed learning and motor performance. Recent evidence has revealed unexpected roles for local inhibitory GABAergic networks in modulating striatal output and behavior.¹ The sparse low-threshold spiking interneuron subtype (LTSI), which exhibits robust reward-circumscribed population activity, is a bidirectional regulator of initial goal-directed learning.² Striatal dopamine signaling is a central reward-related neuromodulatory system mediating goal-directed action and performance, serving as a teaching signal,³ facilitating synaptic plasticity,⁴ and invigorating motor behaviors.⁵ Given the dynamic modulation of LTSIs during goal-directed behavior, we hypothesized that t

SUBMITTER: Holly EN 

PROVIDER: S-EPMC8554636 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature